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Symbol
Name
ID

Bcl10
B cell leukemia/lymphoma 10
MGI:1337994

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating antibody level	Decreased proportion of central memory CD4-positive, alpha-beta T cells	Colitis	Immunodeficiency	Recurrent infections	Infectious encephalitis
Disease(s) Associated with BCL10
immunodeficiency 37

Mouse Phenotypes

decreased B cell proliferation

decreased T cell proliferation

decreased thymocyte number

abnormal B cell differentiation

abnormal T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

decreased mature B cell number

decreased B-1 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

decreased B cell number

increased CD4-positive, alpha-beta T cell number

decreased activated T cell number

increased T cell number

increased single-positive T cell number

increased IgE level

decreased IgG level

decreased IgM level

increased IgM level

decreased immunoglobulin level

abnormal marginal zone B cell physiology

abnormal cytotoxic T cell physiology

abnormal T cell activation

abnormal dendritic cell physiology

abnormal humoral immune response

abnormal immune cell physiology

abnormal cytokine secretion

abnormal response to infection

increased susceptibility to bacterial infection

increased susceptibility to infection

Availability

Mouse Genotype

Bcl10^m1Btlr/Bcl10^m1Btlr

Bcl10^tm1Mak/Bcl10^tm1Mak

Bcl10^tm1Swm/Bcl10^tm1Swm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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